NDI: Collaborative Clinical Research

Principal Investigator: Heather Zwickey, PhD

Abstract: We propose a pilot, open label single-group study for the treatment intervention of gastroenteritis with an alcohol extract of guava leaves (Psidium guajava) in two communities in Ometepe, Nicaragua. One hundred adults who present to either a community clinic in Los Angeles or the outpatient clinic of the hospital in Moyogalpa with diarrhea and/or other gastrointestinal symptoms suggestive of infectious gastroenteritis and who agree to be in this study will take 1 dose of P. guajava three times a day for one week. Before treatment intervention with P. guajava, study participants will be asked to collect up to three stool samples in order to determine if parasites or parasitic ova are present in the gastrointestinal tract via an Ova and Parasite Test (O&P) and, if so, what they are. After one week of treatment intervention with P. guajava participants will then be asked to collect up to three more stool samples, as per O&P protocol.  If parasites and/or ova are still present or if parasites and/or ova are not present and symptoms of gastroenteritis persist, the participant will be treated with Furazolidone, a drug which treats many protazoal and bacterial diarrheas.  This study is designed to elicit an improved understanding of the potential treatment intervention gastroenteritis with a traditional remedy, P. guajava. We intend to evaluate P. guajava’s effect on gastroenteritis followed by investigation of its effects on Giardia spp. This study is collaboration between Natural Doctors International (NDI), a non-governmental organization that delivers natural medicine to underserved communities throughout the world, the Helfgott Research Institute at the National College of Natural Medicine (NCNM), Universidad Nacional Autonoma de Nicaragua, Leon and Labrotorios Isnaya, a phyto-pharmaceuticals laboratory in Nicaragua.