2015-2016 Research

Acupuncture

Acupuncture is an ancient healing practice that originated in China. It is one component of Traditional Chinese medicine, a medical system that has its own system of diagnosis and uses many treatment methods including acupuncture, herbal medicine, massage, bodywork and various meditation practices. Acupuncture stimulates specific areas on the body using ultra thin needles. This stimulation is thought to correct imbalances in the body’s energy flow and internal organs. Helfgott investigators are currently conducting studies looking into the nature of acupuncture points, including developing a device to measure electrical resistance of the skin at acupuncture points.


Projects

Title: Utilization of Group-Based, Community Acupuncture Clinics: A Comparative Study With a Nationally Representative Sample of Acupuncture Users
Principal Investigator:  Chao
Co-Investigator: Kim Tippens ND, MPH, MSAOM

Title: Patient Perspectives on Care Received at Community Acupuncture Clinics: A Qualitative Thematic Analysis
Principal Investigator: Kim Tippens, ND, MSAOM, MPH

Cancer

Cancer development and prognosis can be strongly influenced by nutrition, lifestyle, and the environment. Investigators at Helfgott seek to develop innovative, holistic, and more effective strategies to address cancer at the level of prevention and treatment. In addition to investigating immune-enhancing botanicals and therapies, Helfgott also researches effects of nutritional and mind-body therapies in relation to cancer.

A recent Helfgott study looked at how cruciferous vegetables can affect the genetic regulation of cervical cancer. In addition, Helfgott investigators are evaluating whether mind-body therapies like relaxation and visualization therapy (RVT) can influence cellular immunity; levels of stress, anxiety, and depression; quality of life; and levels of hormones in breast cancer patients.


Projects:

Title: Secular Trends in Health-Related Quality of Life among Older Women with Breast Cancer, 1998-2013
Principle Investigator: Deanne Tibbitts, PhD
Student Investigator: Alex Speers

Diabetes and Metabolic Disorders

Diabetes and pre-diabetic metabolic disorders are on the rise—approximately 20 million people in the U.S. have diabetes and 54 million people have pre-diabetes. In addition, there are one million new cases of type 2 diabetes each year. With diabetes reaching epidemic levels, health care practitioners and researchers have placed an emphasis on how to prevent diabetes before it starts.

Natural medicine excels at managing diseases like type 2 diabetes. Researchers at the Helfgott Research Institute are currently studying ways to prevent and treat diabetes and obesity using natural medicine therapies.


Projects

Title:  Effect of the Probiotic Saccharomyces boulardii on Lipid Levels and Other Cardiovascular Biomarkers
Principal Investigator:  Heather Zwickey, PhD

Title: Pilot Study to Test the Naturopathic Anti-Inflammatory Diet on Inflammatory Markers in Type II Diabetics (A study lead by NUNM in partnership with OHSU)
Principal Investigator: Heather Zwickey, PhD

Title: Survey of CAM Interest, Self-Care, and Satisfaction with Health Care for Type 2 Diabetes at Group Health Cooperative
Principal Investigator: Ryan Bradley ND, MPH

Title: Adjunctive Naturopathic Care for Type 2 Diabetes: Patient-Reported and Clinical Outcomes After One Year
Principal Investigator: Ryan Bradley ND, MPH

Title: Quercetin for Acute Glucose Tolerance in Type 2 Diabetes
Principal Investigator: Marisa Pellegrini, ND
Co-Investigator: Ryan Bradley ND, MPH

Title: Naturopathic Medicine for the Prevention of Cardiovascular Disease: a Randomized Clinical Trial
Principal Investigator: Dugald Seely ND, MS
Co-Investigator: Ryan Bradley ND, MPH

Title: CAM: Naturopathic Dietary Interventions for Patients with Type 2 Diabetes
Principal Investigators: Erica Oberg ND, MPH and Ryan Bradley ND, MPH

Title: Effects of Qigong on Glucose Control in Type 2 Diabetes
Principal Investigator: Guan-Cheng Sun, PhD
Co-Investigator: Ryan Bradley ND, MPH

Title: Associations Between Total Serum GGT Activity And Metabolic Risk: MESA
Principal Investigator: Ryan Bradley, ND, MPH

Title: Effects of A Herbal/Homeopathic Combination Topical Salve on Cutaneous Oxygenation
Principal Investigators: Andrew Erlandsen, ND, Douglas Hanes, PhD, and Ryan Bradley ND, MPH

Evidence-Based Medicine

Projects

Title: eHealth Literacy in NHIS Subpopulations
Principal Investigator: Siobhan Maty, PhD
Student Investigator: Daryl Nault

Title: Research Education Grant: Research in Complementary and Alternative Medicine Program
Funding: NIH R25 Grant

Title: Evidence-Based Medicine Faculty Shadowing Program
Funding: NIH R25 Grant

Education Research

Title: Five-Minute Faculty Teaching Development: Live or Recorded, An Examination of Effectiveness
Principal Investigator: Denise Dallman, ND

Gastrointestinal

Projects

Title:  Multi-Biomarker Exploration of SIBO: an observational study (MBES)
Principal Investigator:  Laurie Menk-Otto, ND, MPH

Title: Effect of a Comprehensive Nutrition Support Product on the Nutritional Status of Adults with Inflammatory Bowel Disease
Principal Investigator: Jenn Ryan, ND

Title:  Impact of IgG Food Sensitivity Elimination Diet in an Overweight/Obese Population
Principal Investigator:  Rachel Neuendorf, ND

Global Health

Projects

Title: West African Birthing Perspectives: A Mixed-Methods Study of Obstetric Practices in Ghanaian Women in the Greater Accra Region
Principal Investigator: Wendy Hodsdon, ND
Student Investigator: Abena Tuson-Turner

Health Services

Projects

Title: Naturopathic Medical Student Perspectives On Disability Health Topics
Principal Investigator: Sarah Hourston, ND

Title: Reliability of Three Constitutional Questionnaires in Ayurveda Diagnosis
Principal Investigator: Carolyn Nygaard, ND & Corina Dunlap, ND

Title: Development of the Sasang Constitutional Analysis Tool (SCAT) among People of European Descent
Principal Investigator: Jenn Ryan ND, MS

Title: NUNM-CR: A Case Report Collection Tool
Principal Investigators: Kim Tippens, MSAOM, MPH and Ryan Bradley ND, MPH

Herbal & Dietary Supplements

Before chemical compounds began to be isolated and used as drugs, there was herbal medicine. Cultures around the world have their own native herbs and traditional use of herbal medicines. As the use of herbal medicine and supplements continues to grow, so does the importance of research on these products to ensure their safety and effectiveness. At Helfgott, traditional use of herbs as medicine meets modern science as we put these remedies to the test.


Projects

Title:  Preliminary Evidence for Potential Phytochemical Synergism in Classical Chinese Herbal Pairs
Principal Investigator:  Morgan Schafer, MA

Title: Effects of MSM on Markers of Oxidative Stress and Muscle Damage Following Exhaustive Exercise
Principal Investigator: Kim Tippens, ND MSOM, MPH
Student Investigator: Eric Withee, MS

Title: Safety Of Hydrastis Mericana, Commiphora Habessinica, Phytolacca Mericana And Echinacea Purpurea Formula And Its Effects On In Vitro Bacterial Growth And In Vivo Human Immune Cell Function
Principal Investigators: Nicole Vasilevsky, PhD

Title: Metagenics: Influence Of An Omega-3 SPM Supplement On Quality Of Life
Principal Investigator: Morgan Schafer, MS

Title: Effect of a Comprehensive Nutrition Support Product on the Nutritional Status of Adults with Inflammatory Bowel Disease
Principal Investigator: Jenn Ryan, ND

Title: Nutritional Status and Quality of Life in Women with Polycystic Ovary Syndrome (PCOS)
Principal Investigator: Corina Dunlap ND, MS

Title: Effect of the Probiotic Saccharomyces boulardii on Cholesterol and Lipoprotein Particles in Hypercholesterolemic Adults: A Single-Arm, Open-Label Pilot Study
Principal Investigator: Jenn Ryan, ND

Title: Epigenetics in Clinical Practice: Characterizing Patient and Provider Experiences with MTHFR Polymorphisms and Methylfolate
Principal Investigators: Erica Oberg, ND & Ryan Bradley ND, MPH

Title: Prospective Safety and Tolerability Assessment of a Cardiovascular Health Dietary Supplement (Carditone)
Principal Investigators: Ryan Bradley ND, MPH & Jenn Ryan ND, MS

Mind-Body

Many studies have shown that thoughts and emotions can have a profound impact on health. Mind-body medicine takes this strong connection into account and uses it to improve overall health. Researchers at Helfgott are investigating the mind-body connection in many ways, including looking at the use of neurofeedback for insomnia, relaxation and visualization therapy for women undergoing breast cancer treatments, and the effects of meditation on heart rate variability.


Projects

Title:  HRV & Autonomic Restoration Visual Environment Stress Trial (HARVEST)
Principal Investigator:  Kurt Beil, ND, LAc, MPH

Title:  Reliability of Three Constitutional Questionnaires in Ayurveda Diagnosis
Principal Investigator:  Corina Dunlap, ND

Title:  Environmental Influence on Holistic Health Measures
Principal Investigator:  Kurt Beil, ND, LAc, MPH

Title:  The Influence of Urban Natural and Built Environments on Physiological and Psychological Measures of Stress–A Pilot Study
Principal Investigator:  Kurt Beil, ND, LAc, MPH

Title: Empathy and Burnout Among Naturopathic Medical Students
Principal Investigator: Melissa Gard, ND

Title: Mindfulness-based Stress Reduction for MS: Feasibility, Durability, and Clinical Outcomes
Principal Investigator: Angela Senders, ND

Title: Meditative Neuroplasticity: The Effect of Qi Gong Meditation on Brain-Derived Neurotrophic Factor and Cortisol Levels
Principal Investigators: Heather Zwickey, PhD, Melissa Gard, ND & Travis Whitney, ND

Title: Psychophysiological Responses to Singing Bowl Therapy: Feasibility Study Examining Practical Outcome Measures
Principal Investigator: Wendy Hodsdon, ND

Title: Qigong for Multiple Sclerosis: A Feasibility Study
Principal Investigator: Angela Senders, ND

NIH Funded Studies & Grants

BRIDG R90 Program

R90 Program Information

T90 Program Information

NUNM Application

NIH T90 and R90 Program Details

Projects

Title: Mindfulness-based Stress Reduction for MS: Feasibility, Durability, and Clinical Outcomes
Principal Investigator: Angela Senders, ND

Title: A Train the Trainer Model For Integrating Evidence-Based Medicine into Complementary and Alternative Medicine Training Program
Principal Investigator: Allen
Co-Investigator: Heather Zwickey, PhD
Funding: R25 NIH Grant

Title: The Vanguard Faculty Program: Research Training for Complementary and Alternative Medicine Faculty
Investigators: Connelly
Co-Investigators: Heather Zwickey, PhD
Funding: R25 NIH Grant

Title: Teaching Evidence-Based Medicine at Complementary and Alternative Medicine Institutions: Strategies, Competencies, And Evaluation
Principal Investigator: Heather Zwickey, PhD
Funding: NIH R25 Grant

OHSU Exchange Program: Evidence-Based Medicine Faculty Shadowing Program

Nutrition

Chronic disease, including diabetes and cardiovascular disease, is on the rise in the U.S., but effective ways to reverse this trend remain elusive. At Helfgott, studying nutritional and mind-body approaches to chronic illness is a strong focus of our research. Previous Helfgott studies have looked at about the efficacy of weight loss methods and the expectancy effects associated with these methods. In addition, Helfgott investigators study a range of diets to determine possible effects on the cellular level and in clinical applications. These nutritional studies include investigations into effects of detoxification diets, cruciferous vegetable supplements and cervical cancer prevention, and the naturopathic Anti-inflammatory Diet’s effects on immune parameters in diabetics and pre-diabetics.


Projects

Title: A Mixed-Method Evaluation of Local Community Health Education on Food Intake and Behavior Change
Principal Investigator:  Kim Tippens, ND, MSAOM, MPH
Student Investigator: Bob Graybill

Title: Effects of MSM on Markers of Oxidative Stress and Muscle Damage Following Exhaustive Exercise
Principal Investigator:  Kim Tippens, ND, MSAOM, MPH
Student Investigator: Eric Withee, MS

Title: Micronutrient Levels In Adults With Autism Spectrum Disorders
Principal Investigators: Heather Zwickey, PhD, Melissa Gard, ND, Morgan Schafer, MS and Sarah Hourston, ND

Title: Pilot Study to Test the Naturopathic Anti-Inflammatory Diet on Inflammatory Markers in Type II Diabetics (in Collaboration with OHSU)
Investigators: Heather Zwickey, PhD, Heather Schiffke, MATCH, and Erin Connelly, ND

Title: Food As Medicine Everyday Research (FAMER): Evaluating Physiological Changes Associated with a Shift toward a Whole-Foods Diet
Principal Investigator: Kim Tippens ND, MSAOM, MPH
Clinical Investigator: Andrew Erlandsen, ND

Title: Effect of a Comprehensive Nutrition Support Product on the Nutritional Status of Adults with Inflammatory Bowel Disease
Principal Investigator: Jenn Ryan, ND, MS

Title: Measuring Subjective Experience of Naturopathic Medicine among Women with Disordered Eating: A Mixed Methods Study
Principal Investigator: Corina Dunlap, ND

Title: Nutritional Status and Quality of Life in Women with Polycystic Ovary Syndrome (PCOS)
Principal Investigator: Corina Dunlap, ND

Title: Physicians’ Attitudes toward and Knowledge of Plant-Based Diets
Principal Investigator: Morgan Schafer, MS

Title: Efficacy and Feasibility of a 12 Week Ketogenic Diet in Patients with Parkinson’s Disease
Principal Investigator: Richard Rosenbaum, MD
Co-Investigators: Angela Senders, ND, Andrew Erlandsen, ND, & Heather Zwickey, PhD

Pain

Pain disorders and pain symptoms are frequently difficult to alleviate, prompting millions of people each year to seek treatment. Complementary and alternative medicine treatments for pain can offer patients another option to potentially more invasive therapies like pharmaceuticals and surgery. Helfgott’s pain research includes an investigation of magnets for carpal tunnel syndrome, relaxation and visualization for radiotherapy burns and other mind-body approaches to chronic fatigue.


Projects

Title:  Osteoarthritis and Peat Mud Pack Therapy
Principal Investigator: Heather Zwickey, PhD
Student Investigator: Lindsay Rodgers

Women’s Health

Projects

Title:  The Association Between Socioeconomic Status and Out-of-Hospital Obstetrical Outcomes
Principal Investigator:  Jill Edwards, ND

Title:  West African Birthing Perspectives: A Mixed-Methods Study of Obstetric Practices in Ghanaian Women in the Greater Accra Region
Principal Investigator:  Wendy Hodsdon, ND
Student Investigator: Abena Tuson-Turner

Title: Measuring Subjective Experience of Naturopathic Medicine among Women with Disordered Eating: A Mixed Methods Study
Principal Investigator: Corina Dunlap, ND

Title: Secular Trends in Health-Related Quality of Life among Older Women with Breast Cancer, 1998-2013
Principle Investigator: Deanne Tibbitts, PhD

Title: Nutritional Status and Quality of Life in Women with Polycystic Ovary Syndrome (PCOS)
Principal Investigator: Corina Dunlap, ND

More info on NIH Projects