The Helfgott Research Institute and the General Clinical Research Center at Oregon Health and Science University (OHSU) are collaborating on a research study to look at the health effects of the naturopathic anti-inflammatory (AI) diet in type 2 diabetics and pre-diabetics. The AI diet is designed to reduce inflammation by eliminating inflammatory and allergenic foods, and promoting anti-inflammatory foods. The AI diet excludes wheat, corn, soy, dairy, beef, pork, nightshade vegetables (peppers, tomatoes, eggplant, and potatoes), citrus fruits, processed oils, alcohol, caffeine, and peanuts. It emphasizes fruits, vegetables, fish, whole grains, and nuts. The excluded foods are thought to either stimulate an inflammatory response in the gastrointestinal tract, or act as an allergen in certain individuals.
Inflammation resulting from consumption of these foods may not be severe, but may contribute to disease pathogenesis in people who are prone to different diseases. The study is being conducted with type 2 diabetics and pre-diabetics because they often have a mild inflammatory response with elevated levels of cytokines, proteins that stimulate an immune response. This study looks at the levels of inflammatory cytokines, glucose and cholesterol in participants who eat the AI diet or a diet based on the American Diabetic Association recommendations for six weeks. If the anti-inflammatory diet reduces inflammatory cytokines, it may be an important diet for people with various conditions, including inflammatory autoimmune diseases such as Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), and IDDM (type I diabetes).